Compound Discoverer 3.3 SP3 software has just been released! We highly recommend upgrading to CD3.3SP3 as soon as possible. This new release contains bug fixes, database updates and some new features, but most importantly it also includes major performance improvements. To access your software from the download site, log in to your account here:   https://thermo.flexnetoperations.com/

In the Release Notes you can find instructions for a “clean” install of CD3.3SP3.  Please keep in mind that different versions of CD (e.g. 3.2 and 3.3) can coexist on the same PC. However this is not the case for service pack versions, for example 3.3.2 and 3.3.3. You need to uninstall your current CD3.3 before installing CD3.3 SP3.

Enhancements made to the Compound Discoverer 3.3 SP3 application:

• Performance improvements: Many computationally intensive data processing nodes, like Detect Compounds, Fill Gaps and Apply mzLogic™, are now executed 2 to 8 times faster, depending on the configuration of the data processing computer.
• Database updates:
  • A new spectral library and mass list with 48,646 structures (Getzinger et. al. , Structure Database and In Silico Spectral Library for Comprehensive Suspect Screening of Per- and Polyfluoroalkyl Substances (PFASs). DOI: 10.1021/acs.analchem.0c04109.) are available for the identification of PFAS compounds. The updated PFAS workflow now also utilizes this database and spectral library.
  • Human Metabolome Database (HMDB) metabolite databases (urine, serum, CSF, saliva, feces, sweat, all metabolites) are now available as mass lists under Lists & Libraries > Mass Lists.
  • A new version of the mzCloud™ Offline Spectral Library (2023) is available under Lists & Libraries > Spectral Libraries.
  • A new version of the Natural Products Atlas database (v2023_06) is available under Lists & Libraries > Mass Lists.
• Molecular Networking: Additional information about compounds and connections can be displayed.
• Support for data acquired on Orbitrap Astral instruments.
• […] and more. For a detailed list of changes please see the Release Notes.